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Universal Twin Screw Pump- The “Can-Do” Twin Screw

September 14, 2018

In today’s post, we wanted to focus on one Waukesha Cherry Burrell’s newest products- the Universal Twin Screw pump.

Twin screw pump technology has been around a long time, but only recently has this technology been used in sanitary pump applications. When properly applied, twin screw technology can offer compelling advantages over other types of sanitary PD pumps.

One of the first differences you’ll notice between twin screw pumps and traditional rotary lobe pumps is the axial motion twin screw pumps use to convey product through the screws. This axial type movement of product allows operation with low NPSH and virtually pulse free pumping. And by adjusting the pitch of the pump screws, twin screw pumps enable very low shear pumping and can handle solids much more gently than rotary lobe pumps

The axial pumping motion of the Waukesha Universal Twin Screw pump also enables the pumps to be run at much higher speeds- up to 3500 RPM. Higher speeds mean greater turndown, giving users the ability to use the Waukesh


The Universal Twin Screw Pump

a Universal Twin Screw pump as both a product AND CIP pump. Twin screw pumps can also handle large amounts of entrained air, making them ideal for pumping out of tanks following cleaning.

Users of Waukesha Cherry Burrell brand pumps have for years benefited from the reliability and consistency their products are known for. The Universal Twin Screw pump is no exception and runs with the same reliability Waukesha is known for, quickly making it the Universal Twin Screw the “Can Do” Twin Screw.

The Universal Twin Screw takes the reliability of twin screw pumping technology to the next level by incorporating non-galling Alloy 88 screws to run with tighter tolerances and through incidental contact by reducing the risk of damage in the event screws make contact with the pump body. Large diameter 17-4 shafts have greater strength than standard stainless steel shafts, helping to reduce vibration and extend seal life. And the 316L product contact body and cover and 304SS gear case allow the Universal Twin Screw to perform in even the most demanding conditions.

One common complaint we’ve heard at Holland about twin screw pumps over the years has been high cost of spares and low levels of support once the pumps have been deployed. Waukesha twin screw pumps are manufactured in Delevan, WI and available through the same industry leading distribution channels that have serviced and supported the high purity process industry for years. Our sales engineers have extensive twin screw experience with most brands of twin screw technology and Factory Certified Holland Service technicians are ready to service any of your twin screw pump needs.

So if you have questions about twin screw pumps or any sanitary positive displacement pump, contact a Holland Sales Engineer today.Cutaway_with_captions_uid5302017503172.jpg

The Universal Pump Base

September 14, 2018

Amazon has ruined the world for everyone.

Hear us out. Amazon is spoiling everyone. Thanks to Prime and other popular online web services, we want everything yesterday.

For years, Holland has focused on delivering to our customers custom solutions for their complex process problems. Your one stop shop for everything sanitary process. Our products are often made to order- sometimes making it hard to deliver yesterday.

Increasingly, the feedback we’re getting from our customers is their desire for standardization and quick turnaround. Incredible value, without sacrificing quality.

Universal Pump Base

The Universal Pump Base

Some might call it, “Sanitary Process Prime”.

Well, after years of development, we are excited to announce the first of a number of steps we’re taking to deliver Sanitary Process Prime- the Universal Pump Base.


At Holland, we’re a lot of things. We build sanitary process skids, fabricate custom flow components, and even crimp hoses. But at the end of the day, we’re an industrial distribution company and a Waukesha Pump dealer. Holland Sales Engineers have been expertly deploying Waukesha’s industry leading line of positive displacement pumps- the Universal 1, 2, and now 3, for years.

After all these years, one of the things we figured out is that every Universal Pump needs a base. But the base is usually the great contributor to lead time. Well, after careful analysis of the hundreds of custom pump/base/drive assemblies we’ve built, we found we could offer a Universal style of base that would cover 70-80% sanitary PD pump applications.

The goal of the Universal Pump Base program is simple- to offer round and square tube pump bases for the U1, U2, and U3 Models 6, 15, 18, 30, 60, and 130 with incredibly quick lead times and tremendous value without sacrificing industry-renowned Holland Quality.

The Universal Pump base is available in both round and square tube designs. Fabricated at our state-of-the-art hygienic fabrication facility, both styles of base are fabricated from 304 Stainless Steel and utilize Holland designed sanitary adjustable feet and all hygienic welds. The standard design is compatible with Sterling Electric 0402A and 0602A gear boxes in TEFC, white washdown, and stainless steel. Bases can even be equipped with an upright for a Lenze AC Tech variable frequency drive, installed and wired by Holland Pump Technicians.

And best of all, with the combination of a Universal Pump Base, our on-hand Waukesha PD pump inventory, and a strategic partnership with Sterling Electric, Holland can now deliver these complete sanitary pump/base/drive assemblies- sized and applied specific to your application- in as little as five days.

For more information on all of our sanitary pump and base offerings, contact a Holland Sales Engineer today.

Waukesha U2 Pumps Mounted on Polished Round Tube Bases

Waukesha Universal 2 Sanitary PD Pumps

Product Focus- The Universal 3 Positive Displacement Pump

September 14, 2018

In today’s post, we wanted to focus on one Waukesha Cherry Burrell’s newest products- the Universal 3 External Circumferential Piston (ECP) pump.

Rotary lobe or External Circumferential Piston pumps have been around for years. And for almost all of those years, Waukesha Cherry-Burrell, an SPX company, has been the industry leader in sanitary ECP Pumps. Starting with the Universal 1, and furthered with the Universal 2 series of PD pump, Waukesha ECP pumps move fluid by drawing it in to the pump head and through two counter-rotating pistons. These pistons, or rotors, sweep along the outside of the pump body and turn at constant velocity.

The shape of the rotors and cavities not only moves the fluid, but deliver a constant volume per unit time for any rotor position. And because all Waukesha pumps use a non-galling Alloy 88 rotor, all Waukesha Universal Pumps have exceptionally tight tolerances and near perfect efficiency with fluids over ~300 CPS.

If you’ve been following our blog, you know we use Waukesha PD pumps across almost every sanitary pumping application. Their simple and robust design allows them to handle both low and high viscosity fluids and delivery metered flow at pressures of up to 500 PSI. They run across a range of speeds, enabling low shear pumping and handling of particulate. The Universal 1 pumps can be easily taken apart and cleaned out of place, while the Universal 2 series of pump is designed to be cleaned in place.

But that’s enough about the Universal 1 and 2 pump. Let’s talk about the latest and greatest- the Universal 3 pump. Optimized for the most grueling of sanitary positive displacement pump applications, the Universal 3 features a front loading seal desigUniversal 3 Pumpn making repair and maintenance a breeze. Have you ever tried to pull the body off a U2 220 that’s connected in line to inspect the seal for damage? It’s a pain in the ass- to say the least.

The new Universal 3 also combines a few other features of the legacy U1 and U2. Like the U2, the Universal 3 is CIP capable standard. The pump body has internal flats that allow it to free drain when the ports are oriented in the vertical. A new cover design also enables free draining on the horizontal or vertical port positions.

Also like the Universal 2, the Universal 3 comes standard with a single mechanical seal with options to convert to a double mechanical seal with flush. And like the Universal 1, the Universal 3 is available with both O ring and lip seals as well, making it ideal for difficult chocolate or confectionary applications.

And while the Universal 3 does come from the same core platform as the U1 and U2, it also integrates years of product research and development, making it the most robust PD pump ever built. The U3 can handle differential pressures of up to 500 PSI and is rated for fluid temperatures up to 300 F. The U3, similar to the U2, has a special rotor nut designed for extended service without loosening. The new pump shafts are shorter and user larger diameter 17-4PH, reducing overhung loads and improving shaft alignment. This decreases seal and bearing wear, extending pump life. The Universal 3 also comes standard with a 304SS gear case.

Dimensionally, the U3 is almost identical to the U1 and U2, allowing drop in replacement of current pumps and cover the same hydraulic range as the U1 and U2. The new U3 is compatible with Holland’s Universal Pump base and Holland Sales Engineers can expertly apply and deliver a U3 for you application in as little as 10 days.

So if you have questions about the new U3 or any sanitary ECP pump, contact a Holland Sales Engineer today.

Holland Applied Technologies- An Overview

June 13, 2018

At Holland, we focus on Quality in everything we do. Check out our new Overview Video to see what Holland Quality means.

BPOG Best Practice Guidelines for Mitigating Risk used in Biopharmaceutical Manufacturing

April 6, 2018

Recently, BPOG (Biophorum Operations Group) has published a guide that relates to mitigating risk in bio manufacturing processes when using single use systems components. A key aspect of the risk mitigation strategy is to consider the potential for chemical entities to migrate from the single use component material into the drug product. Suppliers could aid drug manufacturers with their risk mitigation strategies by generating extractables data on their single use materials. Extractables are typically ‘worst case’ indicators of potential leachables and provide a drug manufacturer with useful information on how to approach future leachables studies.


Key definitions to understand are listed below:


Extractables chemical entities that are able to be extracted from a component of a process system into a solvent under controlled conditions which are usually more aggressive than the normal operating conditions


Leachable’s chemical entities which come from single-use system components that migrate into the drug product during normal use. The single use system consumable qualification process must demonstrate that processing components do not impact the quality of the drug product.

It is important to understand that the product quality should be maintained throughout the drug product lifecycle to ensure that the attributes deemed important to the quality of the drug product are consistent with those evaluated during clinical studies.

One aspect detailed by BPOG and other industry bodies is how to perform risk evaluation.  Risk evaluation is based on assessing the risk to patient safety, product impact manufacturing and regulatory approval. The regulations for drug manufacturers specifically detail that the equipment used in manufacturing of the drug substance shall be constructed so that the surfaces that contact the process material or drug product shall not be, reactive, additive or absorptive.

Risk assessment can be focused on either testing of every single use system component or by taking a risk-based approach where only critical single use system components are tested. The approach taken can be determined by considering the following key attributes

  1. Distance of the single use component to the final drug product or API
  2. Process temperature
  3. Process time
  4. Process fluid interaction
  5. Dilution effects

If you have additional questions about extractables, leachables, or any single use components, contact a Holland Sales Engineer today.

*A Special thanks to Sade Mokuolu @ WMFTG BioPure for her help in putting this blog together

What Sanitary Gasket Material Should I Use? Check out our Chemical Compatibility Guide!

February 10, 2018

With so many options available for elastomers it can be hard to make sure you are selecting the one best suited for your application.  This post is going to go through a few key questions to point you in the right direction.

Let’s start by asking a few important questions about your application:

  • What temperature is your process running at?
  • How are you cleaning your system?
  • What are you trying to seal?

 Once we figure out the answers to those questions, we can start by looking at the three most common elastomers used in the high purity process industry- FKM, Buna, and EPDM. We’re going to leave PTFE out because it isn’t an elastomer- it’s a plastic.

FKM and EPDM are able to handle high temperatures well, and with an upper operating temperature of up to 400 degrees Fahrenheit they are the clear choice for high temperature applications. EPDM is great with steam, but does not mix well with oils. And FKM doesn’t perform as hot at low temperatures, with a lower operating temp of only 5 degrees.

Accordingly, if you are planning on either SIP or CIP, you’ll want to go with FKM or EPDM. SIP uses steam to heat the process line up to at least 250 degrees Fahrenheit, which will cause some strain on your elastomers. If you are going to be running steam frequently through the process line then FKM or EPDM are a good choice for you due to its resiliency against steam and its ability to tolerate the temperature.

For CIP applications, all three elastomers provide good resistance to both acidic and caustic solutions commonly used in CIP procedures although Buna does not tolerate concentrated acids very well.

Before installing a new component you should always make sure that it is chemically compatible with your process fluid. In general, FKM is fairly inert compared to both Buna and EPDM and is well suited to most applications.  But a chemical compatibility chart is available here to check your specific application.

By selecting the proper elastomer you may be able to stretch out the time between replacements.When it is time to replace them or if you have any questions please contact a Holland Sales Engineer.

Sanitary Batching Systems- Weight Addition/Loss in Weight Systems

March 13, 2017

At Holland, we’re no strangers to sanitary batching systems. One of the most common customer challenges we’re asked to solve is a simple batching application. Our customers turn to Holland for a one stop, robust solution that is cost effective and quick to implement. Previous posts have focused on batching systems that are volume based solutions- systems that incorporate a flow meter to control a process. This post will instead focus on weight addition systems and the different system solutions available.

So let’s say you have a recipe for a product you make all the time. A recipe is, by definition, a set of instructions for obtaining a desired outcome. Every recipe has a several ingredients. How we choose to add those ingredients to a receiving vessel is a critical question that must be addressed early in the process design. One way to do it is with a flow meter used to volumetrically measure each ingredient introduced. While this may work well if you only have one ingredient or may be just metering off from a bulk tank, a volumetric system does have its drawbacks. For one, accuracy is limited to accuracy of the flow meter used. In some cases, the meter used is a turbine meter. These can have accuracies that deviate as much as 5%.

Even if the accuracy of your flow meter is sufficient for your application, many recipes call for a mass of product to be added- pounds, kilograms, etc, NOT a volume. To do this, best practice would indicate that we take a direct weight NOT volumetric measurement. When using a volume to add mass, you depend on a density based conversion and depending on processing conditions, fluid density can vary. The only way to do take a direct mass measurement is with a Coriolis meter, which often run well into the tens of thousands of dollars, depending on line size. Can you imagine if you have multiple ingredients, necessitating multiple coriolis meters? You also can’t pass solids or dry products through a flowmeter.

As an alternative to volume based batching systems, let’s consider a weight based alternative. With a weight based system, we use either a floor scale or load cells to measure the weight of either the receiving or dispensing container (a future post will take a closer look at weight by addition vs. weight by loss systems).

For this post, we’ll assume that the receiving vessel is on load cells. With the receiving vessel on load cells, we can add multiple ingredients, liquid or dry, while only measuring one process. This greatly reduces the instrumentation cost of a system. Using a controller, either a PLC or something even simpler, like a Mettler Toledo IND690, valves can be opened and closed, pumps start and stopped once volumes are added. Controllers like the IND690 allow for recipe programming and storage and also have a digital display with tare functions to allow for manual addition if need be.

At Holland, we’re able to take you all the way through system development. We usually start by working with a client to either design and fabricate a batching vessel, or retrofit an existing vessel to accommodate load cells. We then help identify and install auxiliary equipment that is very important AFTER ingredients are batched in- components like mixers, RTDs, and tank outlet valves. Once we identify what you want to measure and how you want to measure it, we can start working on HOW we’re going to add ingredients. This can be by Waukesha PD pump, Masterflex peristaltic pump, or Quattroflow Quaternary diaphragm pump. We can also supply the proper ITT diaphragm or Waukesha seat valve to control flow in. Once that is done, we can work with you to size and select an appropriate floor scale or load cells. Coupled with the right control system, we have a fully functioning batching system, capable of adding a variety of different ingredients and storing several different recipes. So if you have any questions about your next sanitary batching application, contact a Holland Sales Engineer today.

What are Weld Maps and Weld Logs?

February 13, 2017

If you haven’t figured it out yet, at Holland Applied Technologies, we are in the sanitary component and custom systems market and cater exclusively to the high purity process industry. In the high purity process industry, specifically the biopharmaceutical industry, documentation requirements are a key distinguisher between people who play in the industry and those that live in it. One of the most critical processes our customers trust us with is welding of material to create the fluid transfer paths that carry their products. Weld inspection and logging has been and will always be a key part of any Quality Assurance program. But because of the requirements of the US Food and Drug Administration and guidelines outlined by the American Society of Mechanical Engineers Bioprocessing Equipment Standard (ASME BPE), the weld documentation our customers ask us to provide is even more extensive. This post will focus on proper weld documentation specifically weld logs and weld maps- what they are and what information they provide.

Let’s start with the weld map. Weld maps are isometric drawings of the assembly to be welded showing the location with each weld, each weld having its own unique identifying number.  They also contain a bill of material with the part number of each component used in making the assembly. After each weld is completed, it is labeled with a weld number (usually pin stamped on the part) that corresponds to a number on the isometric drawing of the part. When the isometric drawing is reviewed during validation, a third party can use the weld map to quickly identify where on the process piping the weld was performed and then refer to the weld log to ascertain the data discussed above.

Weld logs contain the data specific to each individual weld. Normally a weld log sheet would contain all of the welding information for the welds on a specific isometric drawing.  At the top of any weld log, you’ll usually find client specific project specific information, i.e. project number, job number, etc. You’ll also find the drawing number of for the isometric drawing that the log matches up with. You’ll also see a section for gas lot number of the Argonne gas used for the weld purge as well a block with the signature of the welder who is doing the work.

For our weld logs, the main body of the document has 9 columns for the weld to complete and 3 for the weld inspector.  For each weld, the welding technician first enters the weld number, the date, what piece of welding equipment is being used and which weld procedure is being used.  All of our welding personnel are qualified to specific ASME Section IX weld procedures.  They then enter the heat number for each of the two components to be welded, the size of the tubes being welded and their own initials.

The rest of each line on the weld log is used by the weld inspector.  Each weld is visually inspected by a qualified weld inspector using a boroscope to examine the weld ID.  After inspection he completes the log for that individual weld as to whether it had been boroscoped, did it pass the visual boroscope examination, the inspectors’ signature and the date.


Typical Holland Weld Log

Once this process is completed, these documents, as well as the corresponding material test reports of the components used in the assembly, become part of the turn over package that ships with the system.  Properly executed, you now have a comprehensive package identifying each weld, who made the weld, what components went into the weld and the corresponding material certs for each one of the components.

As we wrap this blog up, let’s not forget why all of this documentation is important. The systems we fabricate at Holland Applied Technologies are used by our customers to manufacture drug products we literally inject into our bodies. And before the drug ever gets made, the system used to make it needs to be validated. Governing bodies like the US Food and Drug administration use the data provided in these logs and maps to approve the manufacturer and manufacturing facility, protecting public health and giving consumers the peace of mind that the medicines they are taking are made on systems and in facilities that comply with current best practices. So if after reading this blog, you have any questions about high purity process welding or documentation requirements, contact a Holland Sales Engineer today.

What are the NEC Requirements for Conduit Fittings in Explosion Proof Applications?

February 3, 2017

4 Cable Seal Off

At Holland, we encounter many electrical system design challenges. Between large biopharmaceutical and food modules, smaller sanitary process skids, pump carts with VFD’s, etc., there are many chances to learn. Recently we had an interesting situation that required us to modify our design to meet a portion of the NEC standard for Hazardous Classified location equipment.

Section 500 of NFPA 70: National Electric Code defines the requirements for building equipment in Hazardous Locations. The standard is broken down into three “Classes”-Class 1 deals with flammable gases and liquids, Class 2 deals with combustible dusts, and Class 3 deals with ignitable fibers. For our purposes, we are concerned with Class 1. This classification defines (among many other things) the requirements for electrical enclosures (which must be explosion proof) as well as the conduit lines that carry electrical cables back to these enclosures.

The requirement of the standard is that all conduit lines must have a seal off located within 18 inches of the purged panel enclosure. Seal offs are (as there name implies) a barrier that is filled with a compound that “provides a seal against the passage of gas or vapors through the seal fitting”, and therefore into the enclosure potentially leading to a dangerous situation. Further, the standard requires that only 25% of the cross sectional area of the sealed fitting can be used up by the conductor wiring. Note that this is significantly less that the 40% allowable area that can be used in all the other fittings in the conduit assembly.

In our case, we realized during field installation that although we met the general 40% requirement, we did not meet the more stringent requirement in the seal off. This situation presented a few options that we had to think through. The first option was to increase the size of the seal off. The standard allows for a larger trade size seal when required to meet this requirement. Unfortunately, Crous-Hinds (as well as Gibson and Calbrite) doesn’t offer a seal off in stainless steel that is larger than 1 inch. There are other options for larger seal offs in other materials of construction (Robroy makes a PVS coated metal conduit (Plasti-Bond) in much larger sizes as well as EYX in galvanized iron), but the specification on this job required stainless steel.

Option two was to reduce the size of the cables. The initial choice was a 3 conductor + ground 18 gauge wire. There are some nice advantages to running multiple conductors, primarily being that it gives more flexibility down the road with device choices (think limit switches, more instrumentation, troubleshooting, etc.). However, in this case we needed to figure how to make this work. We opted to use a 2 conductor with 18 gauge wire, reducing the wire size by more than 30%. This choice met the requirement for cross sectional area of the seal off, effectively getting us in “just under the wire” (ok, I have been waiting to use that) to meet the standard.

Electrical design is a big part of our work at Holland. Hopefully this post will give you some ideas if you run into issues with seal offs and related Class 1 work. Contact one of our Holland Sales Engineers a call if we can help you with a project you are working on.

Product Focus- Aseptiquik DC and Aseptiquik STC

January 30, 2017


Aseptiquck 4.jpg

Aseptiquik DC Sterile Single Use Connectors

For today’s blog post, we’re going to take a look at one of the product lines we saw great growth in 2016- Colder’s line of Aseptic Connectors, Aseptiquik. Specifically, we’ll look at to of the latest additions to the product line, the Aseptiquik DC and Aseptiquik STC. Both products leverage the versatility of the Aseptiquik product line to bring robust solution to very specific biopharmaceutical applications we’ll examine further in this post.

The first product we want to highlight is the Aseptiquik DC connector. This connector is the first all-in-one single technology to offer both a sterile connection AND disconnection. This allows for quick, easy sterile connections and disconnections outside of a sterile environment or laminar flow hood. No sealers, no welders after transfer is complete, just an intuitive click-pull twist. The disconnect is even valved, eliminating the need for a pinch clamp.

Where is this applicable, you may ask? Let’s look at a recent application we helped a customer with. A contract manufacturer recently approached  us to prototype a disposable manifold for them. This client had an application where they were recirculating buffer media over the course of a campaign and over the course of the campaign needed to dose into a disposable bioreactor already equipped with Colder Aseptiquik connectors. Because the campaign ran over a period of weeks, multiple ports were required off the manifold. After buffer was transferred into the bioreactor, a sterile disconnect was preferred. So with the help up Holland, the customer was able to implement a five port single use manifold equipped with seven Aseptiquik DC connectors, allowing for a sterile connection to the plastic media bag and (5) separate sterile connections to the bioreactor.


Single Use 5 Port Manifold with Colder Aseptiquik Connectors

The second product we wanted to highlight is the Aseptiquik STC. Available with both gendered and gender less sterile connectors, the Aseptiquik STC incorporates Colder’s Steam Thru II connector. This combination gives biopharmaceutical manufacturers the flexibility to marry single use and stainless technologies.

Why would this be useful? Imagine you have a stainless steel buffer and bulk product or media received in disposable bag. You need to find a way to steam the vessel and maintain the sterile barrier when you connect the media bag. As we’ve highlighted in a previous post, during an SIP cycle, a Steam Thru II connector is in the “steam on” position, allowing steam to flow through the process equipment, through the Steam Thru connector to a trap, creating a sterile connection between the connector and the stainless vessel. The Aseptiquik connector is then connected to a single use piece of equipment with a matching sterile connector. After this connection is made, the thumb latch on the Steam Thru II connector is pushed and the valve is locked into the fluid flow position, allowing for sterile transfer in or our of the stainless vessel, to or from a single use bag. Because we use a Steam Thru II connector, once transfer is complete, the Steam Thru II can be re-engaged and allow for a “steam off”.

In sum, as biopharmaceutical manufacturing becomes increasingly complex, manufacturer next generation therapies, it is critical that our technologies continue to evolve. The Aseptiquik STC and Aseptiquik DC are two new products we at Holland have recently applied to help customers to address difficult process challenges. If you have a specific question about your biopharmaceutical processing application, contact a Holland Sales Engineer today.